Green Approach for the Synthesis of Copper Oxide Nanoparticles and its Antibacterial Effect against Methicillin-resistant Staphylococcus aureus (MRSA)

Nowadays, nanotechnology has gained promising advantages in the medical and pharmaceutical field by improving delivery of drug to target site. Morinda citrifolia L. belongs genus family Rubiaceae know as ‘Pokok Mengkudu’ Malay. Aqueous extract treated with copper (II) sulfate results formation oxide nanoparticles. The size synthesized nanoparticles (CuONPs) was 10-30nm spherical shape using TEM analysis. UV spectrophotometer showed absorption peak at 306nm. SEM analyses confirm surface morphology shaped particles. FTIR spectroscopy broad bands between 2800 4000 cm−1 C-O, OH, C=O stretch are associated Zeta potential value 21.8 mV -6.45 confirms stability These CuONPs good antibacterial activity against Staphylococcus aureus (ATCC 33591) 20mm, epidermidis 35984) 16 mm, Salmonella typhi, 17mm Escherichia coli 25922) 18mm Vibrio cholerae 20mm. also had significant properties Methicillin-resistance (MRSA) 4330). show synergistic affect along Ceftriaxone, Gentamycin Amoxicillin antibiotic bacterial pathogens respectively.